WS6
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530599

CAS#: 1421227-53-3

Description: WS6 is a beta cell proliferation simulator. WS6 stimulates proliferation of both human beta and alpha cells while maintaining cellular viability and the beta cell differentiated phenotype. WS6 normalized blood glucose and induced concomitant increases in β cell proliferation and β cell number. Affinity pulldown and kinase profiling studies implicate Erb3 binding protein-1 and the IκB kinase pathway in the mechanism of action of WS6. WS6 may help increase human islet mass needed for successful treatment of diabetes.


Price and Availability

Size
Price

1g
USD 3250
Size
Price

2g
USD 5250
Size
Price

5g
USD 8950

WS6, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 530599
Name: WS6
CAS#: 1421227-53-3
Chemical Formula: C29H31F3N6O3
Exact Mass: 568.241
Molecular Weight: 568.6012
Elemental Analysis: C, 61.26; H, 5.50; F, 10.02; N, 14.78; O, 8.44


Synonym: WS6; WS-6; WS 6.

IUPAC/Chemical Name: 4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide

InChi Key: FTODTDQFHDJWIQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)17-21-6-7-22(15-24(21)29(30,31)32)35-26(39)14-19-2-8-23(9-3-19)41-27-16-25(33-18-34-27)36-28(40)20-4-5-20/h2-3,6-9,15-16,18,20H,4-5,10-14,17H2,1H3,(H,35,39)(H,33,34,36,40)

SMILES Code: O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)CC3=CC=C(OC4=NC=NC(NC(C5CC5)=O)=C4)C=C3


Technical Data

Appearance:
White to beige solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Boerner BP, George NM, Mir SU, Sarvetnick NE. WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability. Endocr J. 2015;62(4):379-86. doi: 10.1507/endocrj.EJ14-0449. Epub 2015 Mar 11. PubMed PMID: 25739404; PubMed Central PMCID: PMC4876955.

2: Wrighton KC, Castelle CJ, Varaljay VA, Satagopan S, Brown CT, Wilkins MJ, Thomas BC, Sharon I, Williams KH, Tabita FR, Banfield JF. RubisCO of a nucleoside pathway known from Archaea is found in diverse uncultivated phyla in bacteria. ISME J. 2016 Nov;10(11):2702-2714. doi: 10.1038/ismej.2016.53. Epub 2016 May 3. PubMed PMID: 27137126; PubMed Central PMCID: PMC5113843.

3: Shirakawa J, Kulkarni RN. Novel factors modulating human β-cell proliferation. Diabetes Obes Metab. 2016 Sep;18 Suppl 1:71-7. doi: 10.1111/dom.12731. Review. PubMed PMID: 27615134; PubMed Central PMCID: PMC5021183.

4: Shen W, Tremblay MS, Deshmukh VA, Wang W, Filippi CM, Harb G, Zhang YQ, Kamireddy A, Baaten JE, Jin Q, Wu T, Swoboda JG, Cho CY, Li J, Laffitte BA, McNamara P, Glynne R, Wu X, Herman AE, Schultz PG. Small-molecule inducer of β cell proliferation identified by high-throughput screening. J Am Chem Soc. 2013 Feb 6;135(5):1669-72. doi: 10.1021/ja309304m. Epub 2013 Jan 25. Erratum in: J Am Chem Soc. 2013 Mar 20;135(11):4573. PubMed PMID: 23330637.

5: Remmas N, Melidis P, Zerva I, Kristoffersen JB, Nikolaki S, Tsiamis G, Ntougias S. Dominance of candidate Saccharibacteria in a membrane bioreactor treating medium age landfill leachate: Effects of organic load on microbial communities, hydrolytic potential and extracellular polymeric substances. Bioresour Technol. 2017 Apr 10;238:48-56. doi: 10.1016/j.biortech.2017.04.019. [Epub ahead of print] PubMed PMID: 28432949.

6: de Gannes V, Bekele I, Dipchansingh D, Wuddivira MN, De Cairies S, Boman M, Hickey WJ. Microbial Community Structure and Function of Soil Following Ecosystem Conversion from Native Forests to Teak Plantation Forests. Front Microbiol. 2016 Dec 9;7:1976. doi: 10.3389/fmicb.2016.01976. eCollection 2016. PubMed PMID: 28018311; PubMed Central PMCID: PMC5145857.

7: Hu P, Tom L, Singh A, Thomas BC, Baker BJ, Piceno YM, Andersen GL, Banfield JF. Genome-Resolved Metagenomic Analysis Reveals Roles for Candidate Phyla and Other Microbial Community Members in Biogeochemical Transformations in Oil Reservoirs. MBio. 2016 Jan 19;7(1):e01669-15. doi: 10.1128/mBio.01669-15. PubMed PMID: 26787827; PubMed Central PMCID: PMC4725000.

8: Dojka MA, Harris JK, Pace NR. Expanding the known diversity and environmental distribution of an uncultured phylogenetic division of bacteria. Appl Environ Microbiol. 2000 Apr;66(4):1617-21. PubMed PMID: 10742250; PubMed Central PMCID: PMC92031.

9: Ye M, Yue T, Yuan Y. Effects of sequential mixed cultures of Wickerhamomyces anomalus and Saccharomyces cerevisiae on apple cider fermentation. FEMS Yeast Res. 2014 Sep;14(6):873-82. doi: 10.1111/1567-1364.12175. Epub 2014 Jul 2. PubMed PMID: 24931623.

10: Cardinali-Rezende J, Pereira ZL, Sanz JL, Chartone-Souza E, Nascimento AM. Bacterial and archaeal phylogenetic diversity associated with swine sludge from an anaerobic treatment lagoon. World J Microbiol Biotechnol. 2012 Nov;28(11):3187-95. doi: 10.1007/s11274-012-1129-8. Epub 2012 Jul 25. PubMed PMID: 22828793.

11: Briée C, Moreira D, López-García P. Archaeal and bacterial community composition of sediment and plankton from a suboxic freshwater pond. Res Microbiol. 2007 Apr;158(3):213-27. Epub 2007 Jan 27. PubMed PMID: 17346937.

12: Wu GF, Wu XC, Xuan XD, Zhou XP. Evaluation of nutrient limitation in aquatic ecosystems with nitrogen fixing bacteria. J Environ Sci (China). 2006;18(3):537-42. PubMed PMID: 17294653.

13: Huber JA, Butterfield DA, Baross JA. Bacterial diversity in a subseafloor habitat following a deep-sea volcanic eruption. FEMS Microbiol Ecol. 2003 Apr 1;43(3):393-409. doi: 10.1111/j.1574-6941.2003.tb01080.x. PubMed PMID: 19719671.

14: Dojka MA, Hugenholtz P, Haack SK, Pace NR. Microbial diversity in a hydrocarbon- and chlorinated-solvent-contaminated aquifer undergoing intrinsic bioremediation. Appl Environ Microbiol. 1998 Oct;64(10):3869-77. PubMed PMID: 9758812; PubMed Central PMCID: PMC106571.