GJ-103 sodium
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MedKoo CAT#: 530574

CAS#: 1459687-96-7 (sodium),

Description: GJ103 sodium salt is an active analog of the read-through compound GJ072. Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations.


Chemical Structure

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GJ-103 sodium
CAS# 1459687-96-7 (sodium),

Theoretical Analysis

MedKoo Cat#: 530574
Name: GJ-103 sodium
CAS#: 1459687-96-7 (sodium),
Chemical Formula: C16H13N4NaO3S
Exact Mass: 0.00
Molecular Weight: 364.355
Elemental Analysis: C, 52.74; H, 3.60; N, 15.38; Na, 6.31; O, 13.17; S, 8.80

Price and Availability

Size Price Availability Quantity
100mg USD 750
200mg USD 1150
500mg USD 1950
1g USD 2950
2g USD 4650
5g USD 6750
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Related CAS #: 1459687-96-7 (sodium)   1459687-89-8 (free acid)    

Synonym: GJ-103 sodium;

IUPAC/Chemical Name: sodium 2-((4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetate

InChi Key: PTFQBXAUOWUATD-UHFFFAOYSA-M

InChi Code: InChI=1S/C16H14N4O3S.Na/c1-23-12-6-4-5-11(9-12)20-15(13-7-2-3-8-17-13)18-19-16(20)24-10-14(21)22;/h2-9H,10H2,1H3,(H,21,22);/q;+1/p-1

SMILES Code: O=C(O[Na])CSC1=NN=C(C2=NC=CC=C2)N1C3=CC=CC(OC)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: GJ103 sodium salt is an active analog of the read-through compound GJ072.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 30.0 82.34
DMSO 40.0 109.78
DMSO:PBS (pH 7.2) (1:2) 0.3 0.91

Preparing Stock Solutions

The following data is based on the product molecular weight 364.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Du L, Jung ME, Damoiseaux R, Completo G, Fike F, Ku JM, Nahas S, Piao C, Hu H,
Gatti RA. A new series of small molecular weight compounds induce read through of
all three types of nonsense mutations in the ATM gene. Mol Ther. 2013
Sep;21(9):1653-60. doi: 10.1038/mt.2013.150. Epub 2013 Jun 18. PubMed PMID:
23774824; PubMed Central PMCID: PMC3776636.


2: Lavin MF. Generating SM(a)RTer compounds for translation termination
suppression in A-T and other genetic disorders. Mol Ther. 2013 Sep;21(9):1650-2.
doi: 10.1038/mt.2013.177. PubMed PMID: 24008619; PubMed Central PMCID:
PMC3776641.