ISCK03
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MedKoo CAT#: 407436

CAS#: 945526-43-2

Description: ISCK03 is a potent c-kit inhibitor. ISCK03 inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. ISCK03 also inhibited p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. ISCK03 might be used as skin-whitening agents.


Chemical Structure

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ISCK03
CAS# 945526-43-2

Theoretical Analysis

MedKoo Cat#: 407436
Name: ISCK03
CAS#: 945526-43-2
Chemical Formula: C19H21N3O2S
Exact Mass: 355.14
Molecular Weight: 355.456
Elemental Analysis: C, 64.20; H, 5.96; N, 11.82; O, 9.00; S, 9.02

Price and Availability

Size Price Availability Quantity
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 1950
1g USD 3050 2 Weeks
Bulk inquiry

Synonym: ISCK03, ISCK-03, ISCK 03.

IUPAC/Chemical Name: [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide

InChi Key: YKRCYYGZFGRSAX-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21N3O2S/c1-19(2,3)15-4-6-17(7-5-15)22(25(23)24)18-10-8-16(9-11-18)21-13-12-20-14-21/h4-14,25H,1-3H3

SMILES Code: O=S(N(C1=CC=C(C(C)(C)C)C=C1)C2=CC=C(N3C=CN=C3)C=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: ISCK03 is a specific SCF/c-Kit inhibitor.
In vitro activity: The KIT inhibitor ISCK03 suppressed the production of hemoglobin in K562 cells but did not affect transcription of globin genes. Reference: Biochim Biophys Acta Mol Cell Res. 2021 Mar;1868(3):118931. https://pubmed.ncbi.nlm.nih.gov/33340546/
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 30.0 84.40
DMF:PBS (pH 7.2) (1:5) 0.2 0.56
DMSO 31.5 88.62
Ethanol 2.0 5.63

Preparing Stock Solutions

The following data is based on the product molecular weight 355.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Hirano T, Tsuruda T, Tanaka Y, Harada H, Yamazaki T, Ishida A. Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins. Biochim Biophys Acta Mol Cell Res. 2021 Mar;1868(3):118931. doi: 10.1016/j.bbamcr.2020.118931. Epub 2020 Dec 17. PMID: 33340546. 2. Ma J, Liu X, Chen H, Abbas MK, Yang L, Sun H, Sun T, Wu B, Yang S, Zhou D. c-KIT-ERK1/2 signaling activated ELK1 and upregulated carcinoembryonic antigen expression to promote colorectal cancer progression. Cancer Sci. 2021 Feb;112(2):655-667. doi: 10.1111/cas.14750. Epub 2020 Dec 19. PMID: 33247506; PMCID: PMC7894012.
In vitro protocol: 1. Hirano T, Tsuruda T, Tanaka Y, Harada H, Yamazaki T, Ishida A. Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins. Biochim Biophys Acta Mol Cell Res. 2021 Mar;1868(3):118931. doi: 10.1016/j.bbamcr.2020.118931. Epub 2020 Dec 17. PMID: 33340546. 2. Ma J, Liu X, Chen H, Abbas MK, Yang L, Sun H, Sun T, Wu B, Yang S, Zhou D. c-KIT-ERK1/2 signaling activated ELK1 and upregulated carcinoembryonic antigen expression to promote colorectal cancer progression. Cancer Sci. 2021 Feb;112(2):655-667. doi: 10.1111/cas.14750. Epub 2020 Dec 19. PMID: 33247506; PMCID: PMC7894012.
In vivo protocol: TBD

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1: Na YJ, Baek HS, Ahn SM, Shin HJ, Chang IS, Hwang JS.
[4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits
SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin
production in mice and brownish guinea pigs. Biochem Pharmacol. 2007 Sep
1;74(5):780-6. Epub 2007 Jun 14. PubMed PMID: 17658483.


2: Kamlah F, Hänze J, Arenz A, Seay U, Hasan D, Juricko J, Bischoff B, Gottschald
OR, Fournier C, Taucher-Scholz G, Scholz M, Seeger W, Engenhart-Cabillic R, Rose
F. Comparison of the effects of carbon ion and photon irradiation on the
angiogenic response in human lung adenocarcinoma cells. Int J Radiat Oncol Biol
Phys. 2011 Aug 1;80(5):1541-9. doi: 10.1016/j.ijrobp.2011.03.033. Epub 2011 May
27. PubMed PMID: 21621345.


3: Hirano T, Yoshikawa R, Harada H, Harada Y, Ishida A, Yamazaki T. Long
noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation
of KIT expression. Mol Cancer. 2015 Apr 19;14:90. doi: 10.1186/s12943-015-0364-7.
PubMed PMID: 25928165; PubMed Central PMCID: PMC4423487.