BTB06584
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530497

CAS#: 219793-45-0

Description: BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 inhibited F1 Fo-ATPase activity with no effect on ΔΨm or O2 consumption. BTB06584 efficiency was increased by IF1 overexpression and reduced by silencing the protein.BTB06584 may represent a valuable tool to selectively inhibit mitochondrial F1 Fo-ATPase activity without compromising ATP synthesis and to limit ischaemia-induced injury caused by reversal of the mitochondrial F1 Fo-ATPsynthase.

Chemical Structure

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BTB06584
CAS# 219793-45-0
Instruction

Theoretical Analysis

MedKoo Cat#: 530497
Name: BTB06584
CAS#: 219793-45-0
Chemical Formula: C19H12ClNO6S
Exact Mass: 417.01
Molecular Weight: 417.816
Elemental Analysis: C, 54.62; H, 2.90; Cl, 8.48; N, 3.35; O, 22.98; S, 7.67

Price and Availability

Size Price Availability Quantity
100mg USD 550 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1950
1g USD 2950
2g USD 4650
5g USD 6950
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Synonym: BTB06584; BTB-06584; BTB 06584.

IUPAC/Chemical Name: 2-nitro-5-(phenylsulfonyl)phenyl 4-chlorobenzoate

InChi Key: WNDWKKPBLAKXMI-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H12ClNO6S/c20-14-8-6-13(7-9-14)19(22)27-18-12-16(10-11-17(18)21(23)24)28(25,26)15-4-2-1-3-5-15/h1-12H

SMILES Code: O=S(C1=CC(OC(C2=CC=C(Cl)C=C2)=O)=C([N+]([O-])=O)C=C1)(C3=CC=CC=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 417.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ivanes F, Faccenda D, Gatliff J, Ahmed AA, Cocco S, Cheng CH, Allan E, Russell
C, Duchen MR, Campanella M. The compound BTB06584 is an IF1 -dependent selective
inhibitor of the mitochondrial F1 Fo-ATPase. Br J Pharmacol. 2014
Sep;171(18):4193-206. doi: 10.1111/bph.12638. PubMed PMID: 24641180; PubMed
Central PMCID: PMC4241087.


2: Matic I, Strobbe D, Frison M, Campanella M. Controlled and Impaired
Mitochondrial Quality in Neurons: Molecular Physiology and Prospective
Pharmacology. Pharmacol Res. 2015 Sep;99:410-24. doi: 10.1016/j.phrs.2015.03.021.
Review. PubMed PMID: 25917207.