IDE1
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MedKoo CAT#: 530489

CAS#: 1160927-48-9

Description: IDE1 is a potent cell-permeable definitive endoderm formation inducer (EC50 = 125 nM, ESC) similar to IDE 2 (ab145223). IDE1 induces Sox17 expression. It also activates TGF-β signaling and downstream Smad2 phosphorylation. IDE1 upregulates Nodal expression.

Chemical Structure

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IDE1
CAS# 1160927-48-9
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 530489
Name: IDE1
CAS#: 1160927-48-9
Chemical Formula: C15H18N2O5
Exact Mass: 306.12
Molecular Weight: 306.318
Elemental Analysis: C, 58.82; H, 5.92; N, 9.15; O, 26.12

Price and Availability

Size Price Availability Quantity
50mg USD 450
100mg USD 750
200mg USD 1250
500mg USD 1850
1g USD 2950
2g USD 4250
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Synonym: IDE1; IDE-1; IDE 1.

IUPAC/Chemical Name: 7-[2-(2-Carboxybenzylidene)hydrazinyl]-7-oxoheptanoic acid

InChi Key: ABKJCDILEUEJSH-MHWRWJLKSA-N

InChi Code: InChI=1S/C15H18N2O5/c18-13(8-2-1-3-9-14(19)20)17-16-10-11-6-4-5-7-12(11)15(21)22/h4-7,10H,1-3,8-9H2,(H,17,18)(H,19,20)(H,21,22)/b16-10+

SMILES Code: O=C(O)CCCCCC(N/N=C/C1=CC=CC=C1C(O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: IDE1 is an inducer of definitive endoderm 1.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF:PBS (pH 7.2) (1:1) 0.5 1.63
DMSO 28.5 93.18
Ethanol 0.1 0.33

Preparing Stock Solutions

The following data is based on the product molecular weight 306.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Hoveizi E, Nabiuni M, Parivar K, Ai J, Massumi M. Definitive endoderm differentiation of human-induced pluripotent stem cells using signaling molecules and IDE1 in three-dimensional polymer scaffold. J Biomed Mater Res A. 2014 Nov;102(11):4027-36. doi: 10.1002/jbm.a.35039. PubMed PMID: 24277503.

2: Kobayashi T, Nakayama Y, Itai RN, Nakanishi H, Yoshihara T, Mori S, Nishizawa NK. Identification of novel cis-acting elements, IDE1 and IDE2, of the barley IDS2 gene promoter conferring iron-deficiency-inducible, root-specific expression in heterogeneous tobacco plants. Plant J. 2003 Dec;36(6):780-93. PubMed PMID: 14675444.