4E1RCat
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530395

CAS#: 328998-25-0

Description: 4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions.


Price and Availability

Size
Price

100mg
USD 450
1g
USD 2150
Size
Price

200mg
USD 750
2g
USD 3850
Size
Price

500mg
USD 1250
5g
Ask price

4E1RCat, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530395
Name: 4E1RCat
CAS#: 328998-25-0
Chemical Formula: C28H18N2O6
Exact Mass: 478.1165
Molecular Weight: 478.46
Elemental Analysis: C, 70.29; H, 3.79; N, 5.86; O, 20.06


Synonym: 4E1RCat; eIF4E/eIF4G Interaction Inhibitor II.

IUPAC/Chemical Name: (Z)-4-(3-((5-(4-nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid

InChi Key: BBQRBOIMSKMFFO-PGMHBOJBSA-N

InChi Code: InChI=1S/C28H18N2O6/c31-27-21(16-24-14-15-26(36-24)19-6-12-23(13-7-19)30(34)35)17-25(18-4-2-1-3-5-18)29(27)22-10-8-20(9-11-22)28(32)33/h1-17H,(H,32,33)/b21-16-

SMILES Code: O=C1/C(C=C(C2=CC=CC=C2)N1C3=CC=C(C(O)=O)C=C3)=C\C4=CC=C(C5=CC=C([N+]([O-])=O)C=C5)O4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Shuda M, Velásquez C, Cheng E, Cordek DG, Kwun HJ, Chang Y, Moore PS. CDK1
substitutes for mTOR kinase to activate mitotic cap-dependent protein
translation. Proc Natl Acad Sci U S A. 2015 May 12;112(19):5875-82. doi:
10.1073/pnas.1505787112. PubMed PMID: 25883264; PubMed Central PMCID: PMC4434708.

2: Arnold N, Koppula PR, Gul R, Luck C, Pulakat L. Regulation of cardiac
expression of the diabetic marker microRNA miR-29. PLoS One. 2014 Jul
25;9(7):e103284. doi: 10.1371/journal.pone.0103284. PubMed PMID: 25062042; PubMed
Central PMCID: PMC4111545.