JNJ-10329670

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525302

CAS#: 400797-24-2

Description: JNJ-10329670 represents a novel class of immunosuppressive compounds. JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S. The properties of JNJ 10329670 make it a candidate for immunosuppressive therapy of allergies and autoimmune diseases.

Chemical Structure

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JNJ-10329670
CAS# 400797-24-2
Instruction

Theoretical Analysis

MedKoo Cat#: 525302
Name: JNJ-10329670
CAS#: 400797-24-2
Chemical Formula: C30H34ClF3N6O3S
Exact Mass: 650.21
Molecular Weight: 651.140
Elemental Analysis: C, 55.34; H, 5.26; Cl, 5.44; F, 8.75; N, 12.91; O, 7.37; S, 4.92

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JNJ-10329670; JNJ 10329670; JNJ10329670.

IUPAC/Chemical Name: 1H-Pyrazolo(4,3-C)pyridine, 1-(3-(4-(6-chloro-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)propyl)-4,5,6,7-tetrahydro-5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-

InChi Key: NVAHQQYCEWEDKM-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H34ClF3N6O3S/c1-36-26-9-8-22(31)18-27(26)40(29(36)41)23-10-15-37(16-11-23)13-3-14-39-25-12-17-38(44(2,42)43)19-24(25)28(35-39)20-4-6-21(7-5-20)30(32,33)34/h4-9,18,23H,3,10-17,19H2,1-2H3

SMILES Code: FC(C1=CC=C(C2=NN(CCCN3CCC(N4C5=CC(Cl)=CC=C5N(C)C4=O)CC3)C6=C2CN(S(=O)(C)=O)CC6)C=C1)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 651.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Grice CA, Tays K, Khatuya H, Gustin DJ, Butler CR, Wei J, Sehon CA, Sun S, Gu Y, Jiang W, Thurmond RL, Karlsson L, Edwards JP. The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2209-12. Epub 2006 Feb 3. PubMed PMID: 16458510.

2: Gustin DJ, Sehon CA, Wei J, Cai H, Meduna SP, Khatuya H, Sun S, Gu Y, Jiang W, Thurmond RL, Karlsson L, Edwards JP. Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1687-91. PubMed PMID: 15745822.

3: Thurmond RL, Sun S, Sehon CA, Baker SM, Cai H, Gu Y, Jiang W, Riley JP, Williams KN, Edwards JP, Karlsson L. Identification of a potent and selective noncovalent cathepsin S inhibitor. J Pharmacol Exp Ther. 2004 Jan;308(1):268-76. Epub 2003 Oct 17. PubMed PMID: 14566006.