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LDN-193189

LDN193189 is a highly potent small molecule BMP inhibitor with IC50 of 5 and 30 nM for ALK2 and ALK3, respectively. LDN193189 also inhibits BMP type I receptors ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.

LDN193189 is a highly potent BMP inhibitor, prevents Smad1, Smad5, and Smad8 phosphorylation through inhibition of BMP type I receptors ALK2 (IC50=5nM) and ALK3 (IC50=30 nM). Its inhibition of ALK4, ALK5, and ALK7 is weak (IC50 >500 nM). As BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms, LDN-193189 is used to reduce ectopic ossification in a mouse model.

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