Other drug agents
MedKoo Product Information:
INVANZ (Ertapenem for Injection) is a sterile,
synthetic, parenteral, 1-β methyl-carbapenem that is structurally
related to beta-lactam antibiotics. Chemically, INVANZ is described as
acid monosodium salt. Its molecular weight is 497.50. The empirical
formula is C22H24N3O7SNa. Ertapenem sodium is a white to off-white
hygroscopic, weakly crystalline powder. It is soluble in water and 0.9%
sodium chloride solution, practically insoluble in ethanol, and
insoluble in isopropyl acetate and tetrahydrofuran.
Ertapenem has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of ertapenem results from the inhibition of cell wall synthesis and is mediated through ertapenem binding to penicillin binding proteins (PBPs). In Escherichia coli, it has strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preference for PBPs 2 and 3. Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. Ertapenem is hydrolyzed by metallo-beta-lactamases. Ertapenem has been shown to be active against most isolates of the following microorganisms in vitro and in clinical infections.
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