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TAK-901

Description of TAK-901: TAK-901 is a small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. Aurora B kinase inhibitor TAK-901 binds to and inhibits the activity of Aurora B, which may result in a decrease in the proliferation of tumor cells that overexpress Aurora B. Aurora B is a positive regulator of mitosis that functions in the attachment of the mitotic spindle to the centromere; the segregation of sister chromatids to each daughter cell; and the separation of daughter cells during cytokinesis. This serine/threonine kinase may be amplified and overexpressed by a variety of cancer cell types. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).  

Current developer:    MILLENNIUM/Takeda

 1. Graham, Lauren; Isbester, Paul; Lapina, Olga V.; Mobele, Bingidimi I.; Palmer, Grant J.; Reineke, Karl; Salsbury, Jonathon S.; Ulysse, Luckner. Polymorphs of hydrochloride salt of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide to treat a diseases involving kinase activity. PCT Int. Appl. (2009), 168pp. CODEN: PIXXD2 WO 2009129191 A1 20091022 CAN 151:470178 AN 2009:1298526

2. Brown, Jason W.; Dong, Qing; Gangloff, Anthony R.; Paraselli, Bheema R.; Stafford, Jeffrey A.; Scorah, Nicholas; Salsbury, Jonathon S.; Das, Sanjib. Pyrido[2,3-b]indole derivatives as kinase inhibitors and their preparation and use in the treatment of diseases. PCT Int. Appl. (2009), 536pp. CODEN: PIXXD2 WO 2009129401 A1 20091022 CAN 151:491106 AN 2009:1294139

3. Isbester, Paul; Palmer, Grant J.; Mobele, Bingidimi I.; Salsbury, Jonathon S.; Ulysee, Luckner. Polymorphs of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide for disease treatment. PCT Int. Appl. (2009), 105 pp. CODEN: PIXXD2 WO 2009129259 A2 20091022 CAN 151:470177 AN 2009:1289838

4. Futo, Tomomichi; Nakai, Shinichiro; De Jong, Rinaldo Laurentius; Lee, Bumsup; Christopher, Ronald Joseph. Pharmaceutical compositions containing a cyclodextrin derivative to increase solubility and stability. PCT Int. Appl. (2009), 122pp. CODEN: PIXXD2 WO 2009107877 A1 20090903 CAN 151:322153 AN 2009:1076312

5. Brown, Jason W.; Dong, Qing; Paraselli, Bheema R.; Stafford, Jeffrey Alan; Wallace, Michael B.; Wijesekera, Hasanthi. Preparation of pyridoindoles as kinase inhibiting compounds for treating and preventing kinase-associated diseases. PCT Int. Appl. (2008), 443 pp. CODEN: PIXXD2 WO 2008054956 A2 20080508 CAN 148:495928 AN 2008:556978

6. Brown, Jason W.; Dong, Qing; Paraselli, Bheema R.; Stafford, Jeffrey Alan; Wallace, Michael B. Preparation of pyridoindoles as kinase inhibiting compounds for treating and preventing kinase-associated diseases. PCT Int. Appl. (2008), 439pp. CODEN: PIXXD2 WO 2008045834 A2 20080417 CAN 148:472012 AN 2008:479614

7. Das, Sanjib; Brown, Jason W.; Dong, Qing; Gong, Xianchang; Kaldor, Stephen W.; Liu, Yan; Paraselli, Bheema R.; Scorah, Nicholas; Stafford, Jeffrey A.; Wallace, Michael B. Preparation of pyridoindoles as kinase inhibiting compounds for treating and preventing kinase-associated diseases. PCT Int. Appl. (2007), 362pp. CODEN: PIXXD2 WO 2007044779 A1 20070419 CAN 146:441771 AN 2007:433873