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MedKoo product information:
LY475776
LY475776 is a P-gp inhibitor.
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MedKoo Code#: 401540
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Name: LY475776
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CAS#:
Synonym:
LY475776
IUPAC/Chemical name:
4-azido-N-(((1R,3R)-3-(9-chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)cyclohexyl)methyl)-3-iodobenzamide
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Chemical structure
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Theoretical analysis
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Chemical Formula: C25H22ClIN6O3
Exact Mass: 616.04866
Molecular Weight: 616.83805
Elemental Analysis: C, 48.68; H, 3.59; Cl,
5.75; I, 20.57; N, 13.62; O, 7.78
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Availability and price:
This agent is
not in stock, which may be available through custom synthesis.
To inquire quotation and lead time or to ask questions, please send email to
sales@medkoo.com to describe your needs. A representative
will respond your email shortly. We offer big discount for orders of bulk quantities.
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Information about this agent
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Current developer:
1: Dantzig AH, Shepard RL, Pratt SE, Tabas LB, Lander
PA, Ma L, Paul DC, Williams DC, Peng SB, Slapak CA, Godinot N, Perry WL
3rd. Evaluation of the binding of the tricyclic isoxazole photoaffinity
label LY475776 to multidrug resistance associated protein 1 (MRP1)
orthologs and several ATP- binding cassette (ABC) drug transporters.
Biochem Pharmacol. 2004 Mar 15;67(6):1111-21. PubMed PMID: 15006547.
2: Karwatsky JM, Georges E. Drug binding domains of MRP1 (ABCC1) as
revealed by photoaffinity labeling. Curr Med Chem Anticancer Agents.
2004 Jan;4(1):19-30. Review. PubMed PMID: 14754409.
3: Qian YM, Grant CE, Westlake CJ, Zhang DW, Lander PA, Shepard RL,
Dantzig AH, Cole SP, Deeley RG. Photolabeling of human and murine
multidrug resistance protein 1 with the high affinity inhibitor
[125I]LY475776 and azidophenacyl-[35S]glutathione. J Biol Chem. 2002 Sep
20;277(38):35225-31. Epub 2002 Jul 22. PubMed PMID: 12138119.
4: Mao Q, Qiu W, Weigl KE, Lander PA, Tabas LB, Shepard RL, Dantzig AH,
Deeley RG, Cole SP. GSH-dependent photolabeling of multidrug resistance
protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site
in the COOH-proximal membrane spanning domain. J Biol Chem. 2002 Aug
9;277(32):28690-9. Epub 2002 May 28. PubMed PMID: 12034727.
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Email:
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(Keyword; CAS#; MedKoo code#)
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