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MedKoo product information:
KP372-1
Description of KP372-1:
KP372-1 is a synthetic small molecule AKT inhibitor. KP372-1 is
consisted of two isomers:
KP372-1A
and KP372-1B. KP372-1 showed activities to block signalling
downstream of Akt in thyroid tumour cells, leading to inhibition of
cell proliferation and increased apoptosis. KP372-1 has also
been shown to suppress cell proliferation and induce apoptosis in
gliobastoma.
Current developer:
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MedKoo Code#: 401520
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Name: KP372-1
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CAS#: 329710-24-9
Synonym:
KP372-1
IUPAC/Chemical name:
KP372-1A: 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one
KP372-1B: 6H-indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one
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Chemical structure
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Theoretical analysis
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KP372-1A
KP372-1B
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MedKoo Code#: 401520
Name: KP372-1
CAS#: 329710-24-9
Chemical Formula: C10H4N6O
Exact Mass: 224.04466
Molecular Weight: 224.17836
Elemental Analysis: C, 53.58; H, 1.80; N,
37.49; O, 7.14
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Availability and price:
This agent is available through custom synthesis.
To inquire quotation and lead time or to ask questions, please send email to
sales@medkoo.com to describe your needs. A representative
will respond your email shortly. We offer big discount for orders of bulk quantities.
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Information about this agent
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1: Liu B, Wu JM, Li J, Liu JJ, Li WW, Li CY, Xu HL,
Bao JK. Polygonatum cyrtonema lectin induces murine fibrosarcoma L929
cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling
pathways. Biochimie. 2010 Dec;92(12):1934-8. Epub 2010 Aug 14. PubMed
PMID: 20713122.
2: Shao H, Yi XM, Wells A. Epidermal growth factor protects fibroblasts
from apoptosis via PI3 kinase and Rac signaling pathways. Wound Repair
Regen. 2008 Jul-Aug;16(4):551-8. PubMed PMID: 18638274; PubMed Central
PMCID: PMC2547354.
3: Xi RG, Huang J, Li D, Wang XB, Wu LJ. Roles of PI3-K/Akt pathways in
nanoparticle realgar powders-induced apoptosis in U937 cells. Acta
Pharmacol Sin. 2008 Mar;29(3):355-63. PubMed PMID: 18298901.
4: Li D, Cui Q, Chen SG, Wu LJ, Tashiro S, Onodera S, Ikejima T.
Inactivation of ras and changes of mitochondrial membrane potential
contribute to oridonin-induced autophagy in a431 cells. J Pharmacol Sci.
2007 Sep;105(1):22-33. PubMed PMID: 17895587.
5: Zeng Z, Samudio IJ, Zhang W, Estrov Z, Pelicano H, Harris D, Frolova
O, Hail N Jr, Chen W, Kornblau SM, Huang P, Lu Y, Mills GB, Andreeff M,
Konopleva M. Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine
kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial
dysfunction and apoptosis in acute myelogenous leukemia. Cancer Res.
2006 Apr 1;66(7):3737-46. PubMed PMID: 16585200.
6: Koul D, Shen R, Bergh S, Sheng X, Shishodia S, Lafortune TA, Lu Y, de
Groot JF, Mills GB, Yung WK. Inhibition of Akt survival pathway by a
small-molecule inhibitor in human glioblastoma. Mol Cancer Ther. 2006
Mar;5(3):637-44. PubMed PMID: 16546978.
7: Mandal M, Younes M, Swan EA, Jasser SA, Doan D, Yigitbasi O,
McMurphey A, Ludwick J, El-Naggar AK, Bucana C, Mills GB, Myers JN. The
Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and
anoikis in squamous cell carcinoma of the head and neck. Oral Oncol.
2006 Apr;42(4):430-9. Epub 2006 Jan 27. PubMed PMID: 16442835; PubMed
Central PMCID: PMC1414640.
8: Mandal M, Kim S, Younes MN, Jasser SA, El-Naggar AK, Mills GB, Myers
JN. The Akt inhibitor KP372-1 suppresses Akt activity and cell
proliferation and induces apoptosis in thyroid cancer cells. Br J
Cancer. 2005 May 23;92(10):1899-905. PubMed PMID: 15870708; PubMed
Central PMCID: PMC2361761.
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Contact MedKoo:
Email:
sales@medkoo.com
(Keyword; CAS#; MedKoo code#)
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