CEP-28122 | MedKoo Biosciences

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CEP-28122

Description of CEP-28122: CEP-28122 is a Highly Potent and Selective Orally Active Inhibitor of Anaplastic Lymphoma Kinase with Antitumor Activity in Experimental Models of Human Cancers. (source: Mol Cancer Ther; 11(3); 670-9.)

Current developer: Cephalon (now part of Teva Pharm).

MedKoo Code#: 401213
Name: CEP-28122
CAS#: 1022958-60-6 (CEP-28122 free base); 1354545-57-5 (CEP28122 mesylate salt) Synonym: CEP-28122 IUPAC/Chemical name: (1S,2S,3R,4R)-3-((5-chloro-2-(((S)-1-methoxy-7-morpholino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)amino)pyrimidin-4-yl)amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide
Chemical structure	Theoretical analysis
	Chemical Formula: C28H35ClN6O3 Exact Mass: 538.24592 Molecular Weight: 539.06890 Elemental Analysis: C, 62.39; H, 6.54; Cl, 6.58; N, 15.59; O, 8.90
Availability and price: This agent is available through custom synthesis. To inquire quotation and lead time or to ask questions, please send email to sales@medkoo.com to describe your needs. A representative will respond your email shortly. We offer big discount for orders of bulk quantities.

Information about this agent

In vitro activity of CEP-28122: the follow data was reported by Cheng M et al.

(data reported in Mol Cancer Ther. 2012 Mar;11(3):670-9.)

References

1: Cheng M, Quail MR, Gingrich DE, Ott GR, Lu L, Wan W, Albom MS, Angeles TS, Aimone LD, Cristofani F, Machiorlatti R, Abele C, Ator MA, Dorsey BD, Inghirami G, Ruggeri BA. CEP-28122, a Highly Potent and Selective Orally Active Inhibitor of Anaplastic Lymphoma Kinase with Antitumor Activity in Experimental Models of Human Cancers. Mol Cancer Ther. 2012 Mar;11(3):670-9. Epub 2011 Dec 27. PubMed PMID: 22203728.

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