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MedKoo product information:
AMP423
Description of
AMP423:
AMP423 is a naphthyl derivative of 2-cyanoaziridine-1-carboxamide
with structural similarity to the pro-oxidant anti-tumor agent
imexon.
AMP423 was active in SCID mice bearing 8226/S myeloma and SU-DHL-6
B-cell lymphoma tumors, with a median tumor growth delay (T-C) of 21
days (P = 0.0002) and 5 days (P = 0.004), respectively, and a median
tumor growth inhibition (T/C) of 33.3% (P = 0.03) and 82% (P =
0.01), respectively. In non-tumor-bearing mice, AMP423 was not
myelosuppressive. Mechanistic studies show that AMP423's mode of
cell death is a mixture of necrosis and apoptosis, with generation
of reactive oxygen species, inhibition of protein synthesis, and a
decrease in reduced sulfhydryl levels, but no alkylation of
nucleophiles. Unlike its structural analog imexon, which causes cell
cycle arrest in G(2)/M, AMP423 induces the accumulation of cells in
S-phase. AMP423 has pro-oxidant effects similar to imexon, has
greater cytotoxic potency in vitro, and has anti-tumor activity in
hematologic tumors in vivo. (source: Cancer Chemother Pharmacol.
2011 Dec 21. [Epub ahead of print])
Current developer: xxx
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MedKoo Code#: 401025
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Name: AMP423
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CAS#:
Synonym:
AMP423
IUPAC/Chemical name:
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Chemical structure
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Theoretical analysis
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Availability and price:
This agent is available through custom synthesis.
To inquire quotation and lead time or to ask questions, please send email to
sales@medkoo.com to describe your needs. A representative
will respond your email shortly. We offer big discount for orders of bulk quantities.
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Information about this agent
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Current developer:
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Contact MedKoo:
Email:
sales@medkoo.com
(Keyword; CAS#; MedKoo code#)
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