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MedKoo product information:
AG-1478
AG-1478 is an inhibitor of EGFR kinase with an
IC50 value of 3 nM. It reversibly inhibits rat brain Kv1.5 potassium
channels (IC50 = 9.8 µM) independent of PTK activity. AG-1478 also
inhibits the growth of leiomyoma and myometrium cell cultures with
IC50 values of 5.6 and 5.7 µM, respectively.3 This inhibitor
suppresses MAP kinase activation and strongly inhibits induction of
fos gene expression and DNA synthesis.
Current developer:
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MedKoo Code#: 401019
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Name: AG-1478
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CAS#: 153436-53-4
Synonym:
AG-1478; AG 1478; AG 1478; Tyrphostin AG 1478.
IUPAC/Chemical name:
N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine
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Chemical structure
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Theoretical analysis
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MedKoo Code#: 401019
Name: AG-1478
CAS#: 153436-53-4
Chemical Formula: C16H14ClN3O2
Exact Mass: 315.07745
Molecular Weight: 315.75426
Elemental Analysis: C, 60.86; H, 4.47; Cl,
11.23; N, 13.31; O, 10.13
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Availability and price:
This agent is available through custom synthesis.
To inquire quotation and lead time or to ask questions, please send email to
sales@medkoo.com to describe your needs. A representative
will respond your email shortly. We offer big discount for orders of bulk quantities.
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Information about this agent
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1: Hegab AE, Sakamoto T, Nomura A, Ishii Y, Morishima
Y, Iizuka T, Kiwamoto T, Matsuno Y, Homma S, Sekizawa K. Niflumic acid
and AG-1478 reduce cigarette smoke-induced mucin synthesis: the role of
hCLCA1. Chest. 2007 Apr;131(4):1149-56. PubMed PMID: 17426222.
2: Clayton AH, Perugini MA, Weinstock J, Rothacker J, Watson KG, Burgess
AW, Nice EC. Fluorescence and analytical ultracentrifugation analyses of
the interaction of the tyrosine kinase inhibitor, tyrphostin AG
1478-mesylate, with albumin. Anal Biochem. 2005 Jul 15;342(2):292-9.
PubMed PMID: 15913535.
3: Choi BH, Choi JS, Rhie DJ, Yoon SH, Min DS, Jo YH, Kim MS, Hahn SJ.
Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine
kinase inhibitor. Am J Physiol Cell Physiol. 2002 Jun;282(6):C1461-8.
PubMed PMID: 11997261.
4: Stekelenburg J, Klein BY, Ben-Bassat H, Rojansky N. Opposing effects
of cyclosporin A and tyrphostin AG-1478 indicate a role for Src protein
in the cellular control of mineralization. J Cell Biochem. 1998 Oct
1;71(1):116-26. PubMed PMID: 9736460.
5: Han Y, Caday CG, Nanda A, Cavenee WK, Huang HJ. Tyrphostin AG 1478
preferentially inhibits human glioma cells expressing truncated rather
than wild-type epidermal growth factor receptors. Cancer Res. 1996 Sep
1;56(17):3859-61. PubMed PMID: 8752145.
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Contact MedKoo:
Email:
sales@medkoo.com
(Keyword; CAS#; MedKoo code#)
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